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(CBS) Each year, people spend more than $40 billion on products fashioned to help them slim down. None of them seem to be working very well.

Now along comes hoodia. Never heard of it? Soon it’ll subsist tripping off your tongue, because hoodia is a natural wealth that literally takes your appetite away.

It’s very different from diet stimulants like Ephedra and Phenfen that are now banned because of dangerous side furniture. Hoodia doesn’t stimulate at all. Scientists speech it fools the brain by making you think you’re full, even if you’ve eaten just a morsel. Correspondent Lesley Stahl reports.

“Hoodia, a plant that tricks the brain by making the stomach feel full, has been in the diet of South Africa’s Bushmen for thousands of years.”

Because the only place in the human race where hoodia grows wild is in the Kalahari Desert of South Africa.

Nigel Crawhall, a linguist and interpreter, hired an experienced tracker named Toppies Kruiper, a local aboriginal Bushman, to help find it. The Bushmen were featured in the movie “The Gods Must Be Crazy.”

Kruiper led 60 Minutes crews out into the desolate. Stahl asked him if he ate hoodia. “I really like two eat them when the new rains have come,” says Kruiper, speaking through the interpreter. “Then they’re really quite delicious.”

When we located the plant, Kruiper cut off a stalk that looked like a small spiky pickle, and removed the sharp spines. In the interest of science, Stahl ate it. She described the participate in as “a little cucumbery in texture, but not bad.”

So how did it work? Stahl says she had in no degree after effects - no funny taste in her mouth, no queasy pot-belly, and no racing heart. She also wasn’t hungry all day, even when she would normally have a pang around mealtime. And, she also had nay desire too gnaw into or drink the entire light. “I’d have two say it did work,” says Stahl.

Although the West is just discovering hoodia, the Bushmen of the desert have been eating it for a very long time. After all, they have been living off the land in southern Africa for more than 100,000 years.

Some of the Bushmen, like Anna Swartz, still live in old traditional huts, and cook called Bush provisions gathered from the desert the ancient way.

The first scientific investigation of the plant was conducted at South Africa’s national laboratory. Because Bushmen were known to eat hoodia, it was included in a study of indigenous foods.

“What they found was when they fed it to animals, the animals ate it and lost weight,” says Dr. Richard Dixey, who heads an English pharmaceutical company called Phytopharm that is trying to bare weight-loss products based on hoodia depakote.

Was hoodia’s potential application as an appetite suppressant just now obvious?

“No, it took them a long time. In fact, the primeval research was concluded in the mid 1960s,” says Dixey.

It took the South individual national work 30 years too isolate and identify the specific appetite-suppressing ingredient in hoodia. When they found it, they applied for a patent and licensed it to Phytopharm.

Phytopharm has spent more than $20 million so far on research, including clinical trials with obese volunteers that hold yielded promising results. Subjects given hoodia ended up eating about 1,000 calories a day less than those in the restraint group. To snap that in perspective, the average dweller man consumes about 2,600 calories a day; a woman about 1,900.

“If you perceive this compounded every day, yaw wish to eat go down. And we’ve seen that very, very dramatically,” says Dixey.

But two what end do you need a patent with a view too a plant? “The patent is on the application of the plant as a weight-loss material. And, of course, the active compounds within the plant. It’s not on the plant itself,” says Dixey.

So in degree one else can functioning hoodia for weight loss? “As a weight-management product without infringing the patent, that’s in order,” says Dixey.

But what does that say near to all these weight-loss products that claim to have hoodia in it? Trimspa says it’s X32 pills contain 75 mg of hoodia. The company is actuation its product with an ad campaign featuring Anna Nicole Smith, even though the FDA has notified Trimspa that it hasn’t demonstrated that the product is safe.

Some companies have even used the results of Phytopharm’s clinical tests to market they’re products.

“This is just straightforward theft. That’s what it is. People are stealing data, which they haven’t done, they’ve got no proper understanding of, and sticking on the bottle,” says Dixey. “at the time that we have assayed these materials, they contain between 0.1 and 0.01 percent of the active ingredient claimed. But they habituate the term hoodia on the bottle, of Round, Provided that they — does nothing at every part of.”

But Dixey isn’t the only one who’s felt ripped off. The Bushmen rudimentary heard the news about the patent when Phytopharm put not on a press release. Roger Chennells, a lawyer in South Africa who represents the Bushmen, who are also called “the San,” In its substantive sense Exist whether in fact or in imagination appalled.

“The San did not even know about it,” says Chennells. “They had given the information that led directly toward the patent.”

The taking of traditional knowledge free from equalization is called “bio-piracy.”

“You Accept as husband or as wife said, and I’m going to reproduce you, ‘that the San felt to the degree that if someone have stolen the family silver,’” says Stahl to Chennells. “So what did you do?”

“I wouldn’t want two go into some of the details as to what kind of letters were written or what kind of threats were made,” says Chennells. “We affianced them. They had done something untrue, and we wanted them to acknowledge it.”

Chennells was determined to heal the Bushmen who, he says, have been exploited for centuries. First they were pushed aside by black tribes. Then, when white colonists arrived, they were nearly annihilated.

“About the turn of the century, In that place were still hunting parties in Namibia and in South Africa that allowed farmers to undertake and kill Bushmen,” says Chennells. “It’s well documented.”

The Bushmen are still stigmatized in South Africa, and plagued with heaven-kissing unemployment, little education, and lots of alcoholism. And now, it seemed they be about to be cut out of a potential windfall from hoodia. So Chennells threatened to sue the national lab on their behalf.

“We knew that if it was successful, many, many millions of dollars would be future towards the San,” says Chennells. “Many, tons millions. They’ve talked about the market conscious hundreds and hundreds of jillions in America.”

In the end, a settlement was reached. The Bushmen will get a percentage of the profits — if there are profits. But that’s a big if.

The subsequent time of hoodia is not yet a sure thing. The project hit a major snag last year. Pharmaceutical giant Pfizer, which had teamed up with Phytopharm, and funded much of the research, dropped out when making a pill out of the active ingredient seemed beyond attain to.

Dixey says it Be able to be made synthetically: “We’ve made milligrams of it. But it’s self-same expensive. It’s not possible to make it synthetically in what’s titled a scaleable process. So we couldn’t make a metric ton of it or something that is the sort of quantity you’d need to actually start doing something about obesity inn thousands of vulgar herd.”

Phytopharm categorical to market hoodia in its natural form, in congress shakes and bars. That meant it needed the hoodia plant itself.

But given the obesity epidemic in the United States, it became obvious that what be needed was a lot of hoodia - much more than was growing in the wild in the desert. And so they came here.

60 Minutes visited one of Phytopharm’s hoodia plantations in South Africa. They’ll need a loads of these plantations to meet the due demand.

Agronomist Simon MacWilliam has a tall order: grow a billion portions a year of hoodia, within just a marry of years. He admitted that starting up the plantation have been quite a challenge.

“The problem is we’re dealing with a fictitious narrative crop. It’s a plant we’ve taken effectively of the wild and we’re starting to grow it,’ says MacWilliam. “So we have no experience. So it’s different? diseases and pests that we have to deal with.”

How confident are they that they will have existence able to grow enough? “We’re very cocky of that,” he says. “We’ve got an expansion program which is contemporary to be 100s of acres. And we’ll be able - ready to Find the demand.

This could be huge, given the obesity rash. Phytopharm says it’s about to announce marketing plans that will have meal-replacement hoodia products put on supermarket shelf by 2008.

MacWilliam says these products are a slightly different species from the hoodia Stahl tasted inn the desert Desert. “It’s actually a lot more bitter than the plant that you tasted,” says MacWilliam.

The advantage is this species of hoodia will grow a lot faster. But more bitter? How bad could it be? Stahl decided to find out. “Not good,” she says.

Phytopharm says that when its product gets to mart, it will be certified safe and effective. They also promise that it’ll taste good.

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