In Woman Or Merry Man With Sexual of the Shingles, Aciclovir does Not Prevent Aquisition HIV
Aciclovir, Antivirusnoe medicine, does not reduce the issue HIV-1 in woman or man, who have a shingles sexual, that have a sex with man, according to author of the Article released in June 20, 2008 in Lancet.
The Simplex virus of the Shingles type-2 infections (HSV-2), most inexact reason of the shingles sexual, is bound two on three-pack the increased risk to infections HIV-1. too help two define the universe to this assotiations, Dr. Connie Celum, University Washington, metropolis, USA, and colleagues, studied furniture of the suppression HSV-2 with aciclovir on HIV-1. This be made using negative HIV-, positive women(woman)s HSV-2 in Africa and man, who have a sex with man (MSM) with places in Peru and USA.
In mixed, operated by phase III test, participants were nominated to be mastery 400mg aciclovir (1,637 patients) or (1,640 patients) during 12-18 months. Followups Were Executed monthly to cogitate the distribution a medicine analysis, execute the counsel of the adherence, count of the pill (itself qualified), and mastery counsel of the risk. Each three months, examinations sexual and test HIV whirr executed. The Tested results were an infection HIV-1 and and canker sexual HSV-2.
The Participants were 1,358 womans and 1,814 MSM comprised of analysis: 1,581 in group aciclovir and 1,591 in controlling gruppe. incidence HIV-1 was not vastly another between group. This said, incidence gentical cankers reducted to 47% in group aciclovir, and 65% cankers sexual confirmed two subsist due to HSV-2. Was Not no serious disadvantage event in recorded medication.
In conclusion, authors indicate that aciclovir has an not any influence in factor of the issue HIV-1 in this population. “Our results representation that repressing therapy in the estimation of standard dose aciclovir not efficient in reduction of aquisition HIV-1 in HSV-2 seropositive woman and MSM. The New strategies - it is necessary to break the interaction between HSV-2 and HIV-1.” Additionally, speak, these futher studies must be executed too introduce independently this lack to efficiency is due to absorptions medicine and metabolism, clinical answer of the cankers sexual inn medicine, or firm answer Strong sexual after HSV-2 will is actuated.
The Professor Ronald Gray and Weaver Professor Maria, John Hopkins University, Baltimore, MD, army, accompanying commentary in pron they discuss if management sexual sent infection must be advanced against prevention HIV in negative population HIV. “Thomas Henry author commented that ‘ big tragedy of the science - a murder of the beautiful hypothesis by ugly fact.’ The Time to revalue the hypothesis and too adjust the policy of the prevention accordingly.”
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